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Tovi Lehmann's Research Group: Population Biology of Mosquitoes & Parasites
Our research explores broad population biology questions relevant to patterns of malaria transmission and vector control. Ecological, genetical, behavioral, and molecular approaches are routinely used. We seek discoveries that improve understanding of phenotypic diversity in vector species, its adaptive value, and epidemiological consequences. Studies are conducted at the National Institutes of Health in Rockville, Maryland, and at the Malaria Research and Training Center (MRTC) in Bamako, Mali. The group is nested in the Office of the Chief, LMVR/NIAID/NIH, Dr. Thomas Wellems. Main Research QuestionsHow do aestivation ("dry-season hibernation") and long-distance migration contribute to the persistence of mosquito vectors in areas without surface waters during the dry season? What ecological and evolutionary forces split the molecular forms of An. gambiae from a common gene pool and what mechanisms prevent gene flow between them? What shapes susceptibility to pathogens in natural vector populations?
A new Postdoc position is now open in our group (Apply by November 4, 2013)!
Candidates with external funding are always encouraged to apply.
Group Members
Selected Publications(View more publications by Tovi Lehmann in PubMed.) Lehmann T, Dao A, Yaro AS, Diallo M, Timbiné S, Huestis DL, Adamou A, Kassogu Y, Traor AI 2013. Seasonal variation in spatial distributions of Anopheles gambiae in a Sahelian village: evidence for aestivation. J. Med. Entomol.: In Press. Alvaro Molina-Cruz, Lehmann T and Julia Knckel 2013. Could culicine mosquitoes ever transmit human malaria? Trends in Prasitology: In Press. Dabire KR, Sawadodgo S, Diabate A, Toe KH, Kengne P, Ouari A, Costantini C, Gouagna C, Simard F, Baldet T, Lehmann T, Gibson G. 2013. Assortative mating in mixed swarms of the mosquito Anopheles gambiae s.s. M and S molecular forms, in Burkina Faso, West Africa. Med Vet Entomol. 27:298-312. pdf Maga H, Dabir RK, Lehmann T, Tripet F, Diabat A. 2012. Variation in energy reserves and role of body size in the mating system of Anopheles gambiae. J Vector Ecol. 37:289-97. Abstract Dieter KL, Huestis DL, Lehmann T 2012. The effects of oviposition-site deprivation on Anopheles gambiae reproduction. Parasit Vectors.16:235. pdf Butail S, Manoukis N, Diallo M, Ribeiro JM, Lehmann T, Paley DA. 2012. Reconstructing the flight kinematics of swarming and mating in wild mosquitoes. J R Soc Interface. 9:2624-38. Abstract Huestis DL, Yaro AS, Traor AI, Dieter KL, Nwagbara JI, Bowie AC, Adamou A, Kassogu Y, Diallo M, Timbin S, Dao A, Lehmann T. 2012 Seasonal variation in metabolic rate, flight activity and body size of Anopheles gambiae in the Sahel. J Exp Biol. 215:2013-21. pdf Yaro AS, Traor AI, Huestis DL, Adamou A, Timbin S, Kassogu Y, Diallo M, Dao A, Traor SF, Lehmann T. 2012. Dry season reproductive depression of Anopheles gambiae in the Sahel. J Insect Physiol. 58:1050-9. pdf Diabat A, Yaro AS, Dao A, Diallo M, Huestis DL, Lehmann T. 2011. Spatial distribution and male mating success of Anopheles gambiae swarms. BMC Evol Biol. 28;11:184. pdf Huestis DL, Yaro AS, Traor AI, Adamou A, Kassogu Y, Diallo M, Timbin S, Dao A, Lehmann T. 2011. Variation in metabolic rate of Anopheles gambiae and A. arabiensis in a Sahelian village. J Exp Biol. 15;214(Pt 14):2345-53. pdf Hume JC, Hamilton H 3rd, Lee KL, Lehmann T. 2011. Susceptibility of Anopheles stephensi to Plasmodium gallinaceum: a trait of the mosquito, the parasite, and the environment. PLoS One. 6(6):e20156. pdf Adamou A, Dao A, Timbine S, Kassogu Y, Yaro AS, Diallo M, Traor SF, Huestis DL, Lehmann T. 2011. The contribution of aestivating mosquitoes to the persistence of Anopheles gambiae in the Sahel. Malar J. 6;10:151. pdf Dao A, Kassogue Y, Adamou A, Diallo M, Yaro AS, Traore SF, Lehmann T.2010. Reproduction-longevity trade-off in Anopheles gambiae (Diptera: Culicidae). J Med Entomol. 47(5):769-77. pdf Lehmann T Adama Dao, Alpha Seydou Yaro, Abdoulaye Adamou, Yaya Kassogue, Moussa Diallo Traore Sekou and Cecilia Coscaron-Arias. 2010. Aestivation of the African malaria mosquito, Anopheles gambiae in the Sahel. Am. J Trop. Med Hyg. 83: 601-606. pdf Dao A, Yaya Kassogue, Abdoulaye Adamou, Moussa Diallo, Alpha Seydou Yaro, Sekou F. Traore, and Lehmann T. 2010. Reproduction - longevity trade-off in Anopheles gambiae (Diptera: Culicidae) J Med Entomol. 47:769-77. pdf Diabate A, Dao A, Yaro AS, Adamou A, Gonzalez R, Manoukis NC, Traore SF, Gwadz RW, and Lehmann T. 2009 Spatial swarm segregation and reproductive isolation between the molecular forms of Anopheles gambiae. Proc Biol Sci. 276:4215-22. pdf Manoukis NC, Diabate A, Adamou A, Diallo M, Dao A, Yaro AS, Ribeiro JMC and Lehmann T 2009. Structure and Dynamics of Male Swarms of Anopheles gambiae. Journal of Medical Entomology: In Press. pdf Lehmann T, Hume JCC, Licht M, Burns CS, Wollenberg K, Simard S, and Ribeiro JMC. 2009. Molecular evolution of immune genes in the malaria mosquito Anopheles gambiae. PLoS ONE 4(2): e4549. pdf Dao A, Adamou A, Yaro SA, Maiga HM, Kassogue Y, Traore SF and Lehmann T. 2008. Assessment of alternative mating strategies in Anopheles gambiae (Diptera: Culicidae): Does mating occur indoors? J Med Entomol. 45:643-652. pdf Lehmann T and Diabate A. 2008. The molecular forms of Anopheles gambiae: A phenotypic perspective. [A Review] Infect. Genet. Evol. 8:737-46. pdf Diabate Abdoulaye, Dabire K Roch, Heidenberger Kyle, Crawford Jacob, William Lamp, Culler Lauren, and Lehmann T. 2008. Evidence for Divergence Selection between the Molecular Forms of Anopheles gambiae: Role of Predation. BMC Evolutionary Biology: 11;8:5. pdf Lenhart A, Eigege A, Kal A, Pam D, Miri ES, Gerlong G, Oneyka J, Sambo Y, Danboyi J, Ibrahim B, Dahl E, Kumbak D, Dakul A, Jinadu MY, Umaru J, Richards FO, and Lehmann T. 2007. Contributions of different mosquito species to the transmission of lymphatic filariasis in central Nigeria: Implications for monitoring infection by PCR in mosquito pools. Filaria J. 29;6:14. pdf Kamau L, Munyekenye GO, Vulule JM, Lehmann T. 2007. Evaluating genetic differentiation of Anopheles arabiensis in relation to larval habitats in Kenya. Infect Genet Evol. 7(2):293-7. pdf Diabate A, Dabire RK, Millogo N, Lehmann T. 2007. Evaluating the effect of postmating isolation between the molecular forms of Anopheles gambiae (Diptera: Culicidae). J Med Entomol. 44: 60-4. pdf 300kb Simard F, Licht M, Besansky NJ, Lehmann T. 2007. Polymorphism at the defensin gene in the Anopheles gambiae complex: testing different selection hypotheses. Infect Genet Evol. 7:285-92. pdf Lehmann T, Dalton R, Kim EH, Dahl E, Diabate A, Dabire R, Dujardin JP. 2006. Genetic contribution to variation in larval development time, adult size, and longevity of starved adults of Anopheles gambiae. Infect Genet Evol. 2006: 6(5):410-6. pdf Yaro AS, Dao A, Adamou A, Crawford JE, Ribeiro JM, Gwadz R, Traore SF, Lehmann T. 2006. The distribution of hatching time in Anopheles gambiae. Malar J: 22;5:19 pdf Simard F, Lehmann T 2006. Predicting the Spread of a Transgene in African Malaria Vector populations: Current Knowledge and Limitations. A book chapter in Genetically Modified Mosquitoes for Malaria Control, edited by Christophe Bote. Landes Bioscience/Eurekah Pubmed, Georgetown, TX, USA. pdf 300kb Diabat A, Roch DK, Kengne P, Brengues C, Thierry B, Ouari A, Simard F, and Lehmann T. 2006. Mixed-swarms of the Molecular M and S forms of Anopheles gambiae (Diptera: Culicidae) in sympatric area from Burkina Faso. J. Med. Entomol.: 43: 480-483. pdf 125kb Lehmann T, Marcet PL, Graham DH, Dahl ER, Dubey JP. 2006. Globalization and the population structure of Toxoplasma gondii. Proc Natl Acad Sci U S A. 103(30):11423-8. Epub 2006 Jul 18. pdf Yaro AS, Dao A, Adamou A, Crawford JE, Traore SF, Toure AM, Gwadz R Lehmann T. 2006. Reproductive output of female Anopheles gambiae (Diptera: Culicidae): comparison of molecular forms. J Med Entomol. 43(5):833-9. pdf350kb Diabat A, Roch DK, Kim EH, Ryan D, Niama M, Thierry B, Simard F, Gimnig EJ, Hawley AW, and Lehmann T. 2005. Larval development of the molecular forms of A. gambiae in different breeding sites: a transplantation experiment. J. Med. Entomol. 42:548-53. pdf 150kb Dubey JP, Hill DE, Jones JL, Hightower AW, Kirkland E, Roberts JM, Marcet PL, Lehmann T, Vianna MC, Miska K, Sreekumar C, Kwok OC, Shen SK, Gamble HR. 2005. Prevalence of viable Toxoplasma gondii in beef, chicken, and pork from retail meat stores in the United States: risk assessment to consumers. J Parasitol. 91: 1082-93. pdf Lehmann T, Graham D, Dahl E, and Dubey JP. 2004. Variation in the breeding structure of Toxoplasma gondii and the roles of selfing, drift and epistatic selection in maintaining linkage disequilibria. Inf. Genet. Evol. 4: 107-114 pdf 150kb Dubey JP, Graham, DH De Young RW, Dahl E, Eberhard ML, Nace, EK, Won K, Bishop H, Punkosdy G, Sreekumar C,Vianna MCB, Shen SK, Kwok OCH, Machn M Sumners, JA Demarais, S Humphreys, JG, and Lehmann T. 2004. Molecular and biologic characteristics of isolates of Toxoplasma gondii from wildlife in the United States. J. Parasitol 90: 67-71. pdf Lehmann T, Licht M, Gimnig J, Hightower, A, Vulule, JH, and Hawley WA. 2003. Spatial and temporal variation in kinship among Anopheles gambiae (Diptera: Culicidae) mosquitoes. J. Med. Entomol. 40: 421-429. pdf 150kb Lehmann T, Graham D, Dahl E, Chirukandoth S, Launer F, Corn J, Gamble RH, and Dubey JP. 2003. Transmission dynamics of Toxoplasma gondii on a pig farm. Inf. Genet. Evol. 3: 135-141. pdf 200kb Dubey JP, Graham DH, Dahl E, Sreekumar C, Lehmann T, Davis MF, and Morishita TY. 2003 Toxoplasma gondii Isolates from Free-Ranging Chickens from the United States. J. Parasitol. 89: 1060-2 pdf Donnelly, M. J., Pinto J, Girod R, Besansky NJ, and Lehmann T. 2003. Revisiting the role of introgression vs. shared ancestral polymorphisms as key processes shaping genetic diversity in the recently separated sibling species of the Anopheles gambiae complex. Heredity 92: 61-68 pdf Lehmann T, Licht M, Elissa E, Maega BTA, Chimumbwa JM Watsenga FT, Wondji CS, Simard F, Hawley WA 2003. Population structure of Anopheles gambiae in Africa. Journal of Heredity 94: 133-147. pdf Donnelly M, Simard F, Lehmann T. 2002. Evolutionary Studies of malaria vectors. Trends in Parasitology 18: 75-80. pdf Blackston CR, Dubey JP, Dotson, E, Su C, Thulliez P, Sibley D, and Lehmann T. 2001. High resolution typing of Toxoplasma gondii using microsatellite loci. Journal of Parasitology 87: 1472-1475. pdf Donnelly M, Licht M, and Lehmann T 2001. The effect of past demographic events on population structure of Anopheles gambiae and A. arabiensis. Molecular Biology and Evolution 18: 1353-64. pdf Lehmann T. and Beard B.C. Insect Disease Vectors. 2000. A book chapter in Molecular Epidemiology of Infectious Disease (Ed. R.C.A. Thompson). pp. 283-295. Chapman and Hall London. pdf Lehmann T, Blackston CR, Besansky N, Escalante AA, Collins, FH. and Hawley, W.A. 2000. The effect of the Rift Valley on gene flow between Anopheles gambiae populations in Kenya: the mtDNA perspective. Journal of Heredity 91: 165-8. pdf Lehmann T, Blackston C, Parmley, SF, Remington, JS, and Dubey JP. 2000. Strain typing of Toxoplasma gondii: comparison of antigen-coding and housekeeping genes. Journal of Parasitology 86: 960-971. pdf Lehmann T, Hawley, WA, Grebert, H, and Collins, FH. 1999. The effect of the Rift Valley on gene flow between Anopheles gambiae populations in Kenya. Journal of Heredity: 90: 613-621. pdf 270kb Lehmann T, Hawley, WA, Grebert H, and Collins FH. 1998. The effective population size of Anopheles gambiae in Kenya: implications on population structure. Molecular Biology and Evolution 15:264-276. pdf Lehmann T, Besansky, NJ, Hawley, WA, Kamau, L, Fahey, TG, and Collins, FH. 1997. Microgeographic structure of Anopheles gambiae in western Kenya based on mtDNA and microsatellite loci. Molecular Ecology 6: 243 253. pdf 1.2mb Lehmann T, Hawley WA, Kamau, L, Fontenille D, Simard F, and Collins FH. 1996a. Genetic differentiation of Anopheles gambiae from East and West Africa: comparison of microsatellite and allozyme loci. Heredity 77: 192 200. pdf Lehmann T, Hawley, WA and Collins, FH. 1996b. An evaluation of constraints on microsatellite loci using null alleles. Genetics 144: 1155 1163. pdf Lehmann T, Cupp, MS and Cupp, WE. 1995a. Analysis of migration success of Onchocerca lienalis microfilariae in Simulium vittatum. Journal of Helminthology 69: 47 52. pdf 1mb Lehmann T, Cupp MS and Cupp, WE. 1995b. Chemical guidance of Onchocerca lienalis microfilariae to the thorax of Simulium vittatum. Parasitology 110: 329 337. pdf 1mb Lehmann T. 1994. Reinfestation analysis to estimate ectoparasite population size, emergence and mortality rates. Journal of Medical Entomology. 31: 257 264. pdf Lehmann T, Cupp MS, and Cupp WE. 1994a. Onchocerca lienalis: Rapid clearance of microfilariae within the black fly, Simulium vittatum. Experimental Parasitology 78: 183 193. pdf 2mb Lehmann T, Cupp, MS and Cupp, WE 1994b. Onchocerca lienalis: A comparison of microfilariae loss in Simulium jenningsi and S. vittatum. Experimental Parasitology 79: 195 197. pdf Lehmann T. 1993. Ectoparasites: Direct Impact on host Fitness. Parasitology Today 9: 8 13. pdf 2mb Lehmann T. 1992a. Ectoparasite impact on Gerbillus andersoni allenbyi under natural conditions. Parasitology 104: 479 488.pdf 1mb Lehmann T. 1992b. Reproductive activity of Synosternus cleopatrae in relation to host factors. Journal of Medical Entomology 29: 946 952. pdf
Past Group Members
R. Gwadz's Entomology Section, LMVR, NIH |
Tovi collecting mosquitoes in a hut
The Dry-Season Ecology Team (Mali, 2009)
Muffin searches for scent-tagged mosquitoes in a Baobab hole
Kona indicates putative shelter to Sory
Diana and Yaro measuring metabolic rate
Full Team dissecting mosquitoes (2005)
Launch of aerial traps tethered to Helium filled balloon
Mosquito sorting after knock down
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